AJSM: PRP (Platelet-Rich Plasma) Demonstrates Significant Advantage Over Hyaluronic Acid & Conservative Treatments for Knee OA

Check out this new publication in the American Journal of Sports Medicine (AJSM). The systematic review and meta-analysis included outcomes from 1993 patients.

PRP demonstrated a significantly higher rate of successful outcomes compared with hyaluronic acid (HA) as well as higher rates of patient-reported symptom relief, not requiring a reintervention after the initial injection treatment, and achieving the minimal clinically important difference (MCID) for pain improvement when compared with all alternative nonoperative treatments.

Treatment effects evaluating PRP for knee OA are more robust than approximately half of all comparable meta-analyses in medicine and health care!

It’s nice to see the tipping point when medical societies & major journals are disseminating info on orthobiologics like PRP. Dr Sampson remembers when he started out w/ PRP 17 years ago & docs were skeptical and no conferences would feature PRP.

Now patients should be skeptical if their ortho docs don’t offer PRP as a non-operative option for mild to moderate knee osteoarthritis.

Keep in mind treating the knee comprehensively as an organ (targeting multiple structures vs just a simple joint injection), patient selection/candidacy, platelet dosage, delivery (image guided) & patient experience all make the difference!



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