Research

OrthoHealing Publications

Our respected research team was among the first in the world to publish literature on platelet rich plasma for orthopedic conditions. Additionally, our staff regularly serves as peer reviewers for several leading orthopedic and cellular therapy journals. Further, our doctors continually share our clinical research and introduce new scientific technology by lecturing worldwide and publishing in peer reviewed scientific journals.

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Bone Marrow Cell Therapy

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Biologics in Clinical Setting: Standardization and Collaboration

Dr. Steven Sampson & Dr. Hunter Vincent just published a textbook chapter titled Biologics in Clinical Setting: Standardization and Collaboration. The article describes the importance of education, training and working together to advance the field. More and more textbooks are emerging that serve as a good educational tool for interested physicians to responsibly adapt new cellular technology.

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Biologics for Lumbar Discogenic Pain: 18 Month Follow-up for Safety and Efficacy

Annu Navani, MD, Mary A. Ambach, MD, Raj Navani, MS, and Jason Wei, DO.

May 2018

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Bone Marrow Concentrate for Treatment of Knee Osteoarthritis: A Mini Review

26 April, 2018

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Case Study: Clinical Outcome of Percutaneous Intraosseous Bone Marrow Concentrate (BMC) with Arthroscopy (PIBA) and Platelet-Rich Plasma (PRP) Booster in Severe Osteoarthritis of the Left Hip

December 8, 2017

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Orthobiologics: Where are we Now?

September 14, 2017

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Biologic Therapies for Intervertebral Degenerative Disc Disease: A Review of Novel Applications

March 1, 2017

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Intra-articular bone marrow concentrate injection protocol: short-term efficacy in osteoarthritis.

Aug 16, 2016

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Scientific Poster: Intra-articular bone marrow concentrate injection protocol: short-term efficacy in osteoarthritis.

August 16, 2016

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Innovative Platelet Rich Plasma (PRP) & Bone Marrow Concentrate (BMC) Protocols with New Data for Knee Osteoarthritis.

Healthy Aging Research.

Dec 21, 2015

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Cell therapies for treatment of cartilage and bone disorders: osteoarthritis, avascular necrosis and non-union fractures. Applications of Cell Therapies in Regenerative Treatments of Musculoskeletal Conditions. Volume 7, Issue 4, PMR.

April 2015.

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Early Results with Bone Marrow Concentrate & Emerging Trends in Biologics

Healthy Aging Research 2014, 3 (Suppl 1):A20

Oct 6, 2014

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Scientific Poster: Orthobiologics: A New Frontier of Orthopaedics

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Orthobiologics: A New Generation of Orthopaedics. The past 20 years of medicine has been defined by an unprecedented rate of expansion and scientific discovery.

Apr 15, 2014

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Orthobiologics: A New Frontier for Musculoskeletal Disease. Journal of Cell Research and Transplantion.

2014

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Scientific Poster: Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-Articular Orthobiologic for Cartilage Disease

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Scientific Poster: Bone Marrow Concentrate with and without Arthroscopic Repair for Rotator Cuff Tear: A Case Report

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NEW: Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-Articular Orthobiologic for Cartilage Disease

The Physician and Sportsmedicine. Sept 2013

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Platelet Rich Plasma (PRP)

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Platelet-rich plasma for the treatment of knee osteoarthritis: an expert opinion and proposal for a novel classification and coding system

Elizaveta Kon, Berardo Di Matteo, Diego Delgado, Brian J Cole, Andrea Dorotei, Jason L Dragoo, Giuseppe Filardo, Lisa A Fortier, Alberto Giuffrida, Chris H Jo, Jeremy Magalon, Gerard A Malanga, Allan Mishra, Norimasa Nakamura, Scott A Rodeo, Steve Samspon & Mikel Sánchez

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Current concepts in intraosseous Platelet-Rich Plasma injections for knee osteoarthritis

Diego Delgado, Ane Garate, Hunter Vincent, Ane Miren, Bilbaoc Rikin, Pateld Nicolás Fiz, Steve Sampson, Mikel Sánchez

September 2018

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Education and Standardization of Orthobiologics: Past, Present, and Future

May, 2018

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Education and Understanding Orthobiologics: Then and Now

July 2017 Springer Publishing

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Textbook Chapter: Platelet Rich Plasma in Musculoskeletal Practice

Maffulli, Nicola (Ed.), ISBN 978-1-4471-7271-0

2016.

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Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee

May 31, 2016.

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Regenerative Injection Treatment in the Spine: Review and Case Series with Platelet Rich Plasma. Journal of Cells Research, Reviews & Reports.

April 2015.

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A Call for Using a Standard Biologic Classification System for Future Research: The Rationale for a New Proposed PRP Nomenclature. Applications of Cell Therapies in Regenerative Treatments of Musculoskeletal Conditions. Volume 7, Issue 4, PMR.

April 2015.

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Textbook Chapter: Clinical Aspects of Regenerative Medicine. Translational Regenerative Medicine, edited by Drs. Anthony Atala and Julie Allickson of Wake Forest School of Medicine, Institute of Regenerative Medicine.

Elsevier, Dec 2nd, 2014. Print Book ISBN : 9780124103962, eBook ISBN : 9780124104570.

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Navigating through Biologics and Regenerative Therapies for Chronic Low Back Pain

Healthy Aging Research 2014, 3 (Suppl 1):A15

Oct 6, 2014

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Use of Platelet Rich Plasma for the Treatment of Bicipital Tendinopathy in Spinal Cord Injury: A Pilot Study. British Journal of Sports Medicine.

BMJ 2014

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Textbook Chapter: (Preface Author) Platelet Rich Plasma Practical use in Non-Surgical Musculoskeletal Pathology. Regenerative Medicine- Platelet Rich Plasma: The State Of Art. Innovative Aspects on Preparation and Applications in Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries.

New York: Springer. November 30, 2013 | ISBN-10: 3642401163 | ISBN-13: 978-3642401169 | Edition: 2014.

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Textbook Chapter: Platelet Rich Plasma Practical use in Non-Surgical Musculoskeletal Pathology. Regenerative Medicine- Platelet Rich Plasma: The State Of Art. Innovative Aspects on Preparation and Applications in Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries.

New York: Springer. November 30, 2013 | ISBN-10: 3642401163 | ISBN-13: 978-3642401169 | Edition: 2014.

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NEW: Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients with Chronic Tennis Elbow. A Double Blind, Prospective, Multicenter, Controlled Trial of 230 Patients.

The American Journal of Sports Medicine. July 2013

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Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients with Chronic Tennis Elbow

American Academy of Orthopaedic Surgeons, March 2013

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Platelet-rich plasma therapy as a first-line treatment for severe Achilles tendon tear: a case report

International Journal of Therapy and Rehabilitation. February 2011, Vol 18, No 2.

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Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study

The American Journal of Physical Medicine & Rehabilitation. November 20, 2010 online. December 2010 print.

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Platelet rich plasma injection grafts for musculoskeletal injuries: a review

Curr Rev Musculoskelet Med. December 2008; 1(3-4):165-74.

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Musculoskeletal Ultrasound

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Textbook Chapter: Ultrasound guided Injection of the Femoral nerve. Malanga G and Mautner K. Atlas of Ultrasound-guided Musculoskeletal Injections.

New York: McGraw-Hill.

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Game-Changer: Ultrasound-guided needle procedures offer accurate, cost-effective, and often less painful treatment of musculoskeletal disorders

Imaging Economics, September 2011, Dollars & Sense.

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Management of Dupuytren Contracture With Ultrasound-Guided Lidocaine Injection and Needle Aponeurotomy Coupled With Osteopathic Manipulative Treatment

The Journal of the American Osteopathic Association. Vol 3, No 2. February 2011. 113-116.

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Miscellaneous

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Dept. of Defense Military Issue Brief. How Arthritis Is Threatening Veterans and the U.S. Military.

August 03, 2016.

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Treatment of Medial and Lateral Elbow Tendinosis with an Injectable Amniotic Membrane Allograft – A Retrospective Case Series. Journal of Pain and Relief.

April 2016.

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Scientific Poster: Biomarkers in Osteoarthritis

2015.

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Textbook Chapter: Pirformis Syndrome. Therapeutic Uses of Botulinum Toxin

Springer. 2007 XIV 238p. Humana Press Inc.

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Scientific Poster: Treatment of Medial and Lateral Elbow Tendinosis with an Injectable Amniotic Membrane Allograft - A Retrospective Case Series

TOBI - Orthobiologic Institute, 7th Annual PRP and Regenerative Medicine Symposium

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Scientific Poster: Pulsed Electromagnetic Field Therapy: Potential Clinical Applications & Cellular Mechanisms

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Trying to help, a medical student's experience on 9-11.

The DO. January 2002; 14.

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Peer Reviews

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Enhancement of Atrophic Non-Union Fracture Healing Using Autologous Progenitor Cell-Rich Bone Marrow. The Journal of Cells Research, Development & Therapy. March 2016.

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Therapeutic Efficacy of Platelet-Rich Plasma Injections in Treating Chronic High Hamstring Tendinopathy. Clinical Medical Reviews and Case Reports. Dec 2015.

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Ongoing studies of cell-based therapies for articular cartilage defects in Japan. Orthopedic Research and Reviews. Sept 2014.

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Multiple platelet-rich plasma injections for the treatment of refractory Achilles tendinopathy: results at 4 years. Blood Transfusion. Jan 2014.

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Effectiveness of Platelet-Rich Plasma Injection for Rotator Cuff Tendinopathy: A Prospective Open Label Study. American Journal of Physical Medicine & Rehabilitation. October 2011.

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Evolution of a Therapeutic Innovation for Osteoarthritis Knee: a pilot study in 6 patients. Indian Journal of Medical Research. Feb 2016.

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In vitro study of the role of thrombin in platelet rich plasma (PRP) preparation: utility for gel formation and impact in growth factors release. Journal of Cells and Regenerative Medicine. Oct 2015.

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Can intraarticular injections of autologous mesenchymal cells (MSCs) promote cartilage regeneration in knee osteoarthritis? Progress in Orthopedic Science. March 2015.

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Platelet-rich Plasma compared to corticosteroid injection in long-term patient outcomes of lateral epicondylitis. The Journal of Sport Rehabilitation. May 2014.

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"Effect of activated autologous platelet-rich plasma on chondrogenic differentiation of rabbit bone marrow-derived mesenchymal cells in vitro." Cell Proliferation. April 2014.

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Effect of Platelet-Rich Plasma With or Without Leukocytes on Synoviocytes: An In Vitro Comparative Study. Knee Surgery Sports Traumatology Arthroscopy (KSST). Jan 13, 2014.

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Platelet Rich Fibrin Matrix Effects on Skeletal Muscle Lesions: An Experimental Study. Cells & Materials, August 2011.

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Prospective Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma. American Journal of Physical Medicine & Rehabilitation. March & July 2011.

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Effect of Platelet-Released Growth Factors on Muscle Strain: A Case Control Report. American Journal of Physical Medicine & Rehabilitation. August 2010.

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Platelet-Derived Growth Factors in Muscle Healing. American Journal of Physical Medicine & Rehabilitation. March 2010.

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Platelet-derived growth factors and mesenchymal cells in Regeneration Medicine. Piero Borzini, MD May 2009