Frailty is a geriatric syndrome that often involves decreased muscle strength, weight loss, and lower activity levels. During the aging process, a distinct physiological feature is the decrease in stem cell count as well as its production. A study recently published in Journal of Gerontology shows that intravenous stem cell infusion could ameliorate some of the symptoms related to aging frailty. This study, with a total of 30 subjects divided into three experimental and control groups, investigates the efficacy of human allogeneic mesenchymal stem cell injection. After a month, all subjects, whose ages are between 60 and 95 years, showed no treatment-emergent serious adverse effect, proving evidence for the safety of therapy. At six-month follow up, subjects who received stem cell treatment showed significant improvement in their physical performance, in addition to an increase in inflammatory biomarkers in immune cells. These promising preliminary results may provide effective ways to treat aging frailty and improve the quality of lives for the elderly population. More research is needed to better understand the potential use of stem cells for medical conditions associated with ageing.