Hyaluronic acid injections are currently FDA approved for the management of knee osteoarthritis and are recognized by most major insurance companies as a last alternative to a total knee replacement following failed corticosteroid injection & physical therapy, activity modification, diet, medications, bracing, etc.
15o patients were enrolled and were followed up at 2mo & 6mo. The study demonstrated superior improvements in the PRP treated group that lasted longer. The study added insights which included that younger and more active patients with less cartilage damage did better than those with more advanced arthritis & activity restrictions.
We expect the next realm of clinical trials to includecombining PRP with hyaluronic acid for synergistic effects. Overall the data is scarce on PRP therapy. However every month new articles are coming out, most often favorably. This info is helping us understand the disease process of OA as well.