New research: Cellular and Clinical Analyses of Autologous Bone Marrow Concentrate (BMC) Injection for Knee Osteoarthritis

Congratulations to TOBI Alum Drs. Gregory Lutz and Nicholas Beatty for their contributions to the PM&R journal on the cellular and clinical analysis of autologous bone marrow aspirate (BMA) injections to treat Knee Osteoarthritis.

This prospective observational pilot study looks at the effects of the cellular content in BMA on articular cartilage in patients with mild knee osteoarthritis. Ten patients were included in the overall analysis.  BMA was aspirated from the iliac crest under fluoroscopy or  ultrasound-guide techniques. The main outcome measures were analyzed with respect to total nucleated cell concentration (TNC), mesenchymal stem cell concentrations (MSC), CFU count, and IL-1Ra concentration, whereby sampled assays revealed a wide range of these outcome measures. Researchers found that the actual cellular concentrations samples were lower than the anticipated yield from the device’s manufacturer. Intra-articular injections of BMA to treat knee osteoarthritis appear to be safe and provide potential therapeutic benefit.

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