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Nature, international weekly journal of science: Increase in stem cells with the use of anti-inflammatory medication

Recent research from Indiana University School of Medicine shows a positive correlation between NSAIDs (Non-steroidal anti-inflammatory drugs) use and a boost in stem cells. Traditionally, NSAIDs are restricted prior to procedures such as Platelet-rich plasma (PRP) injection. However, this research suggests that a limited course of Meloxicam (NSAIDs) may increase stem cell count in PRP. Before this is recommended on a regular basis, more data is needed.

Researchers first studied the mice model. They injected mice with both, the stem cells and with Meloxicam. Increases in stem cell counts along with the long-term viability of the cells were witnessed. Next, the researchers treated 4 non-human primates (baboons) and found a boost in stem cells. Lastly, healthy human volunteers were treated with Meloxicam and significant increase in stem cells was observed.

This is an important concept that could change cancer treatment protocols. This could potentially enhance procedures such as PRP Platelet Rich Plasma. We spoke with the leading scientist regarding patients that were on chronic (long-term) NSAIDs, This research is the first step in developing more advanced protocols for the future. Long term use of these medications have been associated with severe side effects including stomach bleeding and ulcers. More trials are needed to clarify if they have a role in regenerative injection procedures.


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