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Posts tagged ‘knee arthritis’

New study in American Journal of Sports Medicine shows Platelet Rich Plasma (PRP) blood injection superior to placebo for knee osteoarthritis treatment.

Tuesday, January 15, 2013 by Steven Sampson D.O.

In a new study from the American Journal of Sports Medicine, researchers in India were able to show that when compared to a placebo control of saline (water), PRP patients had superior benefits. There was a mild deterioration of those improvements at 6 months. This level 1 randomized placebo controlled study showed that PRP injection for knee osteoarthritis is safe and effective. Of note, supporting prior studies and literature; patients with more mild degrees of cartilage damage fared better than those with advanced disease. This suggests that earl intervention is key in active individuals to keep tehm active whiel protecting the knee & avoiding potentially harmful treatments like cortisone injections. More powerful biologic treatments are emerging for more advanced cases of cartilage damage including Bone Marrow Concentrate (BMC)m, although more controlled trials are needed. Since our initial publication of PRP use in knee arthritis, many studies have shown that it has a strong safety profile & is helpful.



New Study shows PRP Platelet Rich Plasma injections are superior to Hyaluronic Acid Injections for knee osteoarthritis

Monday, October 3, 2011 by Steven Sampson D.O.

A new study from Italy published in Arthroscopy, showed superiority in PRP injections over the standardof care with hyaluronic acid injections.

 Hyaluronic acid injections are currently FDA approved for the management of knee osteoarthritis and are recognized by most major insurance companies as a last alternative to a total knee replacement following failed corticosteroid injection & physical therapy, activity modification, diet, medications, bracing, etc.

15o patients were enrolled and were followed up at 2mo & 6mo. The study demonstrated  superior improvements in the PRP treated group that lasted longer. The study added insights which included that younger and more active patients with less cartilage damage did better than those with more advanced arthritis & activity restrictions.

We expect the next realm of clinical trials to includecombining PRP with hyaluronic acid for synergistic effects. Overall the data is scarce on PRP therapy. However every month new articles are coming out, most often favorably.  This info is helping us understand the disease process of OA as well.



Dr Steven Sampson to lecture at North America Platelet Rich Plasma Symposium Toronto, Canada Sept 9, 2011

Tuesday, September 6, 2011 by Steven Sampson D.O.

We’re excited to announce that Dr Sampson will be joining leading physicians from around the world for an imformative symposium on PRP. The North America PRP Symposium  is an international collaboration to update the latest trends & studies on PRP and regenerative medicine. Live demonstrations will occur as well. Dr Sampson will be lecturing specifically on PRP use in Osteoarthritis.

The seminar will feature leading physicians including :

Co-Moderator – Michael Clarfield,MD

The Sports Medicine Specialist, Tornonto, Ontario

Co-Moderator – Gordon Ko,MDSunnybrook Health Sciences Centre, Markham, Ontario


Jon Jacobson,MD University of Michigan, Department of Radiology


Sherwin Kevy, MDImmune Disease Institute, Harvard University, Boston, MA


Ken Mautner, MDEmory Healthcare, Atlanta, GA


Joseph Purita, MDBoca Raton Orthopedic Group, Boca Raton, FL


Steve Sampson, DOThe Orthohealing Center, Los Angeles, CA


Michael Scarpone, DORiverside Medical, Steubenville, OH


Henry Stiene, MDBeacon Orthopaedics & Sports Medicine, Cincinnati, OH




Dr Steven Sampson Summer/Fall Lecture Schedule

Wednesday, July 20, 2011 by Steven Sampson D.O.

Evidence of the growing momentum behind regenerative medicine & better science, more medical organizations are inquiring about cost effective alternatives to surgery including PRP (Platelet Rich Plasma) Therapy. Dr Steven Sampson of the Orthohealing Center will be lecturing on PRP & regenerative medicine:

Wed Aug 27: Southern California Rheumatology Society, Los Angeles, CA

Sat Aug 6, Kaiser Permanente, 2011 Combined Physical Medicine-Rehabilitation, Pain Management & Occupational Medicine Symposium. Los Angeles, CA

Sat Sept 10, 2011: North American PRP Symposium. Toronto Canada.



Several New PRP Platelet Rich Plasma Osteoarthritis Studies Underway!

by Steven Sampson D.O.

Following our initial publication of PRP Therapy for knee osteoarthritis in Dec 2010, several studies are underway looking at larger sample sizes to determine if PRP is safe & effective for the treatment of knee osteoarthritis. In a study by Wang & Cugat, 808 patients received 3 PRP injections at 2 week intervals. The study demonstrated improved function, quality of life & pain with no adverse events reported.

An Australian based Co Adistem, Just announced it’s ethical approval for a head to head study of PRP to Synvisc One (A commonly used US FDA approved Lubricant  for knee arthritis). lastly, Dr Brian Cole, the Chicago Bulls Team Doc & leading cartilage researcher is conducting a trial with Arthrex/ACP injections for knee osteoarthritis.

More recently, industry leaders in orthobiologics are recognizing the tremendous need for alternative treatments to surgery in a population that will see an increase for total knee replacements skyrocket 670% by 2030. We expect to see more & more trials with larger patient #’s and better science to emerge in the near future.



New Study in American Journal of Sports Medicine shows PRP Platelet Rich Plasma Therapy more effective than cortisone injection at 2 Year Follow up

Thursday, March 31, 2011 by Steven Sampson D.O.

The March 2011 edition of The American Journal of Sports Medicine published an article that showed superior results in pain and function from PRP Platelet Rich Therapy Injection compared to a cortisone shot at 2 year follow up. The controlled blinded study is the largest of it’s kind involving 2 Dutch teaching Hospitals. Overall 100 patients with tennis elbow (lateral epicondylitis) were involved in the study.

More & more studies are emerging on PRP therapy. Not all will be positive do the the variablity of study design, injection technique with or without ultrasound or x-ray guidance, platelet concentration, and severity of existing injury.

Nonetheless we’ve seen this procedure come along way in the nearly 5 years since we began conducting research & treating patients with PRP.  We are principal investigators in the largest US controlled & blinded clinical trial on PRP involving 12 centers to determine if PRP injections are a safe & effective treatment for tennis elbow. Enrollment has been complete for almost 2 months with 230 patients.

A recent study in Orthopedics also demonstrated efficacy in PRP treatment for golfers & tennis elbow.

Performing reserach takes lots of time & resources, however as clinicians we have a responsibility to document our work & add the the field of regenerative medicine to maximize benefits & safety to our patients. There is much skepticism in the media regarding this novel therapy & many others. What most don’t realize is that publishing a 2 year study of this magnitude requires considerable time & resources. Congrats to the authors. Our 1 year knee arthritis PRP study took years to reach publication with lack of resouces etc.



Orthohealing Center featured in Cleveland Clinic Arthritis Advisor

Tuesday, March 29, 2011 by Steven Sampson D.O.

We are proud to announce that Dr Steven Sampson’s PRP Knee Osteoarthritis study was featured in the March 2011 edition of the Cleveland Clinic Arthritis Advisor. The journal features innovative treatments for Osteoarthritis & we’re thrilled to be included in the prestigious patient friendly publication.

While Dr Sampson’s study included a small # of patients, it paves the way for further research to examine which conditions may best respond to PRP. Major institutes like the Cleveland clinic, Harvard University/Massachusetts  General Hospital, & HSS are featuring this innovative therapy.

We have seen increased interest from Doctors abroad, who will be attending our upcoming PRP seminar in Los Angeles, CA. Attendees are coming from Monaco, Philippines, Singapore, Saudi Arabia, Japan, Spain & more!  By bringing like minded docs together we can further the advancement of regenerative medicine.



Orthohealing Center Publishes New Article on PRP Platelet Rich Plasma Therapy for Knee Osteoarthritis

Monday, December 6, 2010 by Steven Sampson D.O.

We are proud to announce another Orthopedic publication from our center this year. The December 2010 issue of the American Journal of Physical Medicine & Rehabilitation features:

Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study 

While limited by lack of industry funding and a small sample size, the article is an attempt to document our work and educate the medical and public community about emerging cell based therapies and regenerative medicine. The study will be used as a platform to launch a multi-center clinical trial to determine if PRP is a safe & effective for treatment of Knee  Osteoarthritis.




Orthohealing Center Dr Steven Sampson interviewed by Massachusetts General Hospital Proto Magazine on Platelet Rich Plasma Therapy for Arthritis

Thursday, May 6, 2010 by Steven Sampson D.O.

Massachusetts General Hospital’s magazine Proto, recently interviewed Dr Steven Sampson of the Orthohealing Center regarding the use of PRP for osteoarthritis. Major hospitals like Mass General are becoming increasingly aware of the emerging field of orthobiologics that includes PRP and stem cell based therapies. Studies are showing that PRP may potentially reduce infection rates in surgeries like cardiac bypass(CABG)  which can save lots of expenses for hospitals and improve outcomes. Another pioneer in , Elizaveta Kon of the Rizzoli Orthopaedic Institute in Bologna Italy recently completed a studyshowing PRP to be more effective than another OA treatment, hyaluronic acid. Dr Sampson’s PRP knee arthritis study is pending publication.



Platelet Rich Plasma PRP in Wall Street Journal

Tuesday, March 30, 2010 by Steven Sampson D.O.

PRP has been receiving more attention in the media with many professional athletes receiving this treatment. This am the Wall Street Journal featured PRP. Many studies were reported at the annual meeting of the American Academy of Orthopaedic Surgeons found that PRP was effective at treating chronic tennis elbow, severe Achilles tendinitis and osteoarthritis of the knee. One study demonstrated that using a particular PRP concentration device was unsuccessful with intra-operative use in rotator cuff repairs.

Other interesting links from the Ortho conference & PRP from Web MD & Arthritis Today:




We agree that more research is needed to determine which protocols & which specific injuuries have a better prognosis with PRP. We recently submitted our 12 month follow up study on patients with knee arthritis & PRP.



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